- α-Ketoglutarate dictates AMPK protein synthesis for energy . . . - Nature
Together, our findings link α-KG to energy sensing through AMPK translation and propose that targeting α-KG–YBX1-dependent AMPK translation can sensitize human cancer cells to energy stress
- α-Ketoglutarate dictates AMPK protein synthesis for energy . . .
Together, our findings link α-KG to energy sensing through AMPK translation and propose that targeting α-KG-YBX1-dependent AMPK translation can sensitize human Cancer cells to energy stress for treatment
- α-Ketoglutarate dictates AMPK protein synthesis for energy . . .
Together, our findings link α-KG to energy sensing through AMPK translation and propose that targeting α-KG–YBX1-dependent AMPK translation can sensitize human cancer cells to energy stress for treatment
- AMP-activated protein kinase: An energy sensor and survival mechanism . . .
In eukaryotic cells, the highly conserved AMP-activated protein kinase (AMPK) serves as the main sensor of cellular energy status AMPK is activated by an upsurge in the cytosolic ratio of AMP:ATP or ADP:ATP, which is the result of compromised cellular energy status
- 复旦大学发表最新Nature子刊论文_腾讯新闻
2025 年 8 月 22 日，复旦大学代谢与整合生物学研究院李福明团队联合中国科学院分子细胞卓越科学创新中心 西湖大学 季红斌团队（米雯、薛云为共同第一作者）在 Nature Chemical Biology 期刊发表了题为：α-ketoglutarate dictates AMPK protein synthesis for energy sensing in human cancers 的研究论文。 该研究发现，代谢物 α-酮戊二酸（α-KG）通过 TET-YBX1 信号轴调控 AMPK 蛋白的合成，进而调控人类特有的癌细胞能量感知能力并抵抗双硫死亡（Disulfidptosis）。
- 复旦大学发表最新Nature子刊论文_澎湃号·湃客_澎湃新闻 . . .
在这项最新研究中，研究团队发现，代谢物 α-酮戊二酸（α-KG）通过 TET-YBX1 信号轴调控 AMPK 的翻译和 AMPK 蛋白的合成，这一机制可用于增强人类癌细胞对能量应激的敏感性。
- AMP-activated protein kinase—an energy sensor that regulates all . . .
AMP-activated protein kinase (AMPK) is a sensor of energy status that maintains cellular energy homeostasis It arose very early during eukaryotic evolution, and its ancestral role may have been in the response to starvation
- Ampk alpha2 T172 activation dictates exercise performance and energy . . .
INTRODUCTION Adenosine 5′-monophosphate (AMP)–activated protein kinase (AMPK) is a critical energy-sensing molecule within skeletal muscle that has several established roles in regulating glucose uptake, fatty acid oxidation, and overall metabolic plasticity at rest, during exercise, and in response to exercise training (1 – 5)
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